Now that you know, what will you do?

Most human diseases are the result of a combination of genetic susceptibility, environmental exposure and behavioral risk factors. While we can’t control our genes, we can take steps to limit the influence of environment and behavior on our health.

Researchers at Scripps Genomic Medicine in San Diego, are studying the influence of genetic testing on health outcomes. The study is called the Scripps Genomic Health Initiative. Laura Ornowski, N.P., Clinical Trial Manager, says investigators want to know if people who are aware of their risk for certain future health problems are willing to take steps to reduce their risk.

Participants will submit a saliva sample for DNA testing. The sample is sent to Navigenics, a certified laboratory, for processing. Scientists will scan the DNA for genetic markers associated with 23 medical conditions (like Alzheimer’s disease, brain aneurysm, colon cancer, type 2 diabetes, heart attack and macular degeneration).

Ornowski says each participant receives an approximately 80 page assessment with the results. The report provides information on which diseases a person is at risk for, and how genes and the environment influence those risks. Participants are also given information on what steps can be taken to reduce their risk for those conditions. Navigenics has a team of experts available to answer any questions that may arise from the report. Ideally, patients will take the genetic assessment to their physician to discuss their health risks and ways to prevent or reduce the chance of developing the disease(s).

Participants will be followed to determine if or how the information from the genetic tests influences their health and lifestyle decisions. Each person will complete a self-reported health assessment at the beginning of the study and then other assessments three and twelve months after receiving the results from genetic testing. The participants will also conduct periodic follow-up assessments of behavior and health over the next 20 years.

Normally, the cost of a genetic screening is about $2,500. However, in conjunction with Scripps researchers, Navigenics is offering the test to participants for $470.00. The study is open to anyone 18 and older. The last date for enrollment is June 30, 2009. For more information, go to